Antibody Engineering & Therapeutics

FUJIFILM Diosynth Biotechnologies will be presenting at Antibody Engineering & Therapeutics Virtual Conference December 14-16, 2020. Presentation details below. Want to learn more; visit our virtual booth and connect with our Commercial Development team.

You’re invited to attend:

Date: December 15, 2020

Time: 2:45pm-3:15pm EST

Presenter: Nicholas Barber, Principal Scientist, Cell Culture Process Development,
FUJIFILM Diosynth Biotechnologies, Billingham, United Kingdom

Title: Combining Directed Evolution and Droplet Microfluidics to Increase Titers and Reduce Cell Line Development Timelines

Abstract: Reducing the timeline to GMP manufacture poses a challenge for CHO cell line development workflows that attempt to strike a balance between the speed of the process, the quality of the cell line produced and assurance of monoclonality. We have investigated approaches to optimize this balance through a combination of development effort, which includes (i) reducing the number of cloning steps, whilst maintaining a high assurance of monoclonality, through the use of single cell imaging and high resolution plate imaging technology (ii) screening cellular heterogeneity in a predictive high-throughput mode at an early stage of the cell line development workflow (iii) creating a host cell line that inherently exhibits desirable biomanufacturing attributes, including higher titers, without compromising product quality attributes.

For the complete agenda and to register for the conference please visit Antibody Engineering & Therapeutics