Home About Us Events Webinar: Rapidly identifying high quality clonal cell lines during Apollo™X CHO cell line development

Webinar: Rapidly identifying high quality clonal cell lines during Apollo™X CHO cell line development

September 17, 2020

 

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Virtual Lunch & Learn
Date: Thursday – September 17, 2020
Time:11:00am-12:00pm EST
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Title: Rapidly identifying high quality clonal cell lines during Apollo™X CHO cell line development

Apollo™X represents an evolution from our original Apollo™ platform, accomplished with the application of screening technology, enhanced media selection and our scientists’ technical expertise. Apollo™X features include:

  • Improved timelines achieving 10 g/L in 10 weeks from transfection to Research Cell Bank (RCB)
  • Improved CHO DG44 host cell line, developed and selected to be scalable with long term commercial manufacturability
  • Application of CytoMine® technology to achieve statistically robust monoclonality with a single step cloning approach
  • Integrated cell line and process development approach designed to achieve expedited IND filings
  • No royalties/fees for manufacturing customer; fully portable after 1 x cGMP run

Most recently, FUJIFILM Diosynth Biotechnologies has integrated Cergentis’ proprietary Targeted Locus Amplification (TLA) technology into our Apollo™ X cell-line development as a powerful tool for targeted, complete sequencing of transgenes and integration sites. TLA identifies all transgene integration sites and detects all single-nucleotide variants (SNVs) and structural variants in an integrated transgene sequence.

This webinar will:

  • Pinpoint key Apollo™ X features
  • Introduce Cergentis’ proprietary Targeted Locus Amplification (TLA) technology for transgene & integration site characterization
  • Present how the TLA technology allows FUJIFILM Diosynth Biotechnologies to support rapid genetic characterization of clonal cell lines during Apollo™ X cell-line development and clone selection. This includes early confirmation of recombinant-gene integrity and identification and elimination of clones that produce aberrant protein products.

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